Policies Governing Research Grants and Fellowships

A. FOCUS OF HUNTER'S HOPE RESEARCH PROJECTS
Projects funded by Hunter's Hope investigate new treatment approaches for Krabbe or other leukodystrophies or study basic mechanisms related to these diseases. Areas of relevant research include, among others: gene therapy; myelin development; neuro-degeneration and transplantation; developmental neurobiology and molecular biology.

B. APPLICATION DEADLINES & PROJECT START DATES
Grants can be submitted any time, but only exceptional research directly related to a treatment/cure for Krabbe disease will be considered.

C. DEFINITIONS

APPLICANT: An individual requesting funding in association with a sponsoring institution.

PRINCIPAL INVESTIGATOR is the researcher/applicant applying for a research grant.

FELLOW: (Post Doctoral Research Fellow). An individual who has completed graduate training and holds a Ph.D., M.D., DVM, or equivalent degree and who is not more than five (5) years from the time of obtaining their terminal degree; who is a junior investigator, in postdoctoral training, engaged in research early in the development of his or her career; who is not an established independent investigator or a tenured faculty member, and who works under the direct supervision of a Sponsor, within a Sponsoring Institution.

SPONSOR: An established research scientist associated with a Sponsoring Institution who supervises and oversees the work of the Fellow to ensure that the scientific aims of the research project and the Fellow are met.

SPONSORING INSTITUTION: An accredited academic institution that supports scientific research, a research hospital accredited by the Joint Commission on Accreditation of Healthcare Organizations, and any nationally or internationally recognized research organization.

D. ELIGIBILITY OF APPLICANTS
Grant applicants must be associated with accredited academic institutions, JCAHO accredited research hospitals, or other non-profit research organizations that have national and international reputations for excellence, and must be deemed eligible by their academic institution to apply for research grants. Applicants must hold a Ph.D., M.D., DVM, or equivalent degree. There are no restrictions as to age, race, religion, sex, creed, national origin or any other protected characteristic of an applicant. There are no restrictions as to the geographical location of the sponsoring institution or the residence of the applicant. There are no restrictions on the number of times an individual, including previously funded Fellows and Principal Investigators, may apply for a grant.

E. ELIGIBLE COST CATEGORIES FOR PROJECT BUDGETS, DEFINED
The following define the cost categories allowed in projects funded by Hunter's Hope. Please note that not every cost category defined here is applicable to all three types of research projects. Please refer to Section F, Description of Project Categories for the specific cost categories allowed for each type of project.

• Salaries and fringe benefits for personnel, at rates commensurate with the prevailing rates of the Sponsoring Institution and the amounts of personnel time dedicated to the project. Fringe benefits are generally accepted to be medical insurance, life insurance, disability, retirement benefits, and similar benefits.
• Project-related travel not exceeding $1,000 per any one year of funding.
• Indirect costs to the sponsoring institution at a maximum rate of 10% of the total personnel costs (salary support plus fringe benefits) of the approved grant budget. Indirect costs should be calculated as inclusive of the total grant budget.
• Supplies, including lab supplies, animal costs, and other direct project expenses.
• Technical support, including costs associated with collaborations and other types of assistance necessary to the project.

• Capital development programs
• Building construction or renovations
• Computers or other general office equipment or furnishings
• Other major equipment purchases. However, the Foundation may consider specific requests on an individual basis if equipment is considered vital to the project and cannot be obtained in any other way.

F. DESCRIPTION OF PROJECT CATEGORIES
Grants are awarded in three project categories: Major Research Projects, Fellowships, and Pilot Research Projects. The maximum grant award, the term of the award, allowable cost categories, and PI qualifications vary from one type of grant to another. Please review the following sections carefully for information specific to the type of grant for which you are applying.

MAJOR RESEARCH GRANTS
Project Term: One to three years.
Maximum Award: $100,000 per year.
Principal Investigator Qualifications: Eligible applicants are experienced, independent investigators. Research fellows, residents, and other persons in training are not eligible for this category of funding.
Allowable cost categories:

• Salaries and fringe benefits
• Research-related travel
• Indirect costs
• Supplies

POSTDOCTORAL FELLOWSHIPS
Project Term: Two-year award.
Maximum Award: $40,000 to $60,000 per year, at a level consistent with the schedules set forth by the sponsoring institution, and competitive and commensurate with the years of postdoctoral study and training of the applicant.
Additional Qualifications of the Fellow: Only postdoctoral fellows with greater than 90% of his/her efforts devoted to research are eligible for funding under a Hunter's Hope fellowship, and only if the sponsor who directs the research has a research program related to the neurosciences. (These requirements supplement, and do not replace, the eligibility criteria established for Hunter's Hope awards generally.)
Allowable cost categories: Postdoctoral Fellowship Awards shall be used for the sole purpose of stipend or salary support of the Fellow, and if applicable, for project-related travel expenses of the Fellow.

PILOT RESEARCH GRANTS
Project Term: One year. A renewal, for a maximum of one additional year, can be requested for particularly promising pilot grants. Additional support is only available thereafter through application for a Major Research Grant.
Maximum Award: $30,000 annually for the one-year project.
Principal Investigator Qualifications: Applicants for these awards should be independent investigators; active scientists holding the degree of Ph.D., M.D., DVM, or equivalent degree and having appointments at colleges, universities or research foundations. It is expected that applicants will have expertise and a history of productivity in related scientific areas.
Additional Notes: The intent of the Pilot Research Grant Program is to initiate research in entirely novel directions, and to test ideas that enhance the possibility of identifying cures for Krabbe disease and other leukodystrophies.
Allowable cost categories:

• Salaries & fringe benefits (Support staff only; PI salary & fringe not allowed)
• Supplies
• Technical support
• Indirect costs
• Project-related travel

G. THE REVIEW PROCESS FOR GRANT PROPOSALS
The Hunter's Hope Scientific Advisory Board reviews all funding requests and makes recommendations to the Foundation's Board of Directors. The Scientific Advisory Board is comprised of experts in the fields of neurology, neurobiology, molecular biology, immunology, genetics, and related fields who serve on a volunteer basis. The Scientific Advisory Board does not provide comments or scores from the review process to the applicant.

The Board of Directors of the Hunter's Hope Foundation awards grant funds based upon the recommendations of the Scientific Advisory Board, the availability of funds, and other pertinent factors.

H. NOTIFICATION OF AWARDS
After the review and evaluation process is completed, the Hunter's Hope Foundation will notify all applicants of the outcome of their request.

OTHER TERMS AND CONDITIONS GOVERNING HUNTER'S HOPE GRANT AWARDS

I. ACCEPTANCE OF AWARD
A grantee indicates acceptance of an award, and the terms and conditions outlined herein, by accepting and depositing funds disbursed by the Hunter's Hope Foundation. If a grantee cannot accept the award, including the legal obligation to perform in accordance with its provisions, it must notify the Hunter's Hope Foundation immediately upon receipt of the initial funds disbursement and this agreement. Any funds already disbursed must be returned to Hunter's Hope in full.

If a Hunter's Hope Foundation grant is not activated for any reason within six months of the commencement date of that grant, that grant will be terminated. Any funds already disbursed must be returned to Hunter's Hope in full.

J. FUNDS DISBURSEMENT POLICY AND REPORTING REQUIREMENTS

• The first installment will be 10% of the total award upon receipt of the signed research agreement. Reimbursement for expenditures thereafter will be issued at two, four, or six months following the initial disbursement, contingent upon the timely receipt of reports and satisfactory project progress.
• Required reports consist of two parts-a narrative progress report and a budget and expenditures report. Expenditure reports may be submitted and reimbursed at two-month intervals, but progress reports are due every six months. Grantees may use their own established accounting and record-keeping systems as long as those procedures produce accurate and complete documentation of program results and expenditures.
• Principal Investigators are required to attend the Hunter's Hope Foundation Annual Scientific and Medical Symposium and present their work to the Foundation in both lay and scientific presentations.
• The Hunter's Hope Foundation reserves the right to request, at our discretion, additional information related to the progress of the project or the project budget, or to schedule a site review of the project.

K. EXPENDITURE RESPONSIBILITY
Funds disbursed under this grant award must be expended in accordance with the budget approved for the project, and for the purposes specified in the applications submitted to the Hunter's Hope Foundation. Prior approval must be obtained from the Foundation if expenditures in any cost category are expected to deviate by 25% or more. In such case, written budget modification requests, including a clearly stated justification for the change, must be submitted at least 30 days prior to the date such change is proposed to become effective. Any funds not expended in accordance with the terms of an approved budget for the project must be returned to the Foundation.

L. CHANGES TO PROJECT DESCRIPTION AND WORK PLAN
Grantees are expected to adhere to the specific aims, goals and work plan approved for funding by the Hunter's Hope Foundation. Requests to modify the approved project description or work plan must be submitted in writing to the Hunter's Hope Foundation at least 60 days prior to the date such changes are proposed to become effective. The following are examples of changes that require prior approval:

• Substitution of one animal model for another
• Any change from the approved use of animals or human subjects
• Applying a new/different technology from that outlined in the project application
• A change in key personnel whose expertise is critical to the approved project
• Significant re-budgeting (see preceding paragraph)

M. AVAILABILITY AND ACKNOWLEDGEMENT OF RESEARCH RESULTS AND POLICY REGARDING PATENTS AND INVENTIONS
It is the intention and the goal of the Hunter's Hope Foundation to make available to the public and the scientific community the results and accomplishments of the research it funds, and to ensure that leukodystrophy patients have access to any therapies thus developed.

• Investigators funded by Hunter's Hope are expected to share research resources developed with the Foundation's support with other qualified investigators funded by Hunter's Hope.
• All inventions made with the support of the Hunter's Hope Foundation must be promptly reported to the Foundation in writing. With respect to any such invention, the Investigator or the Institution shall have the right to file a patent application, but if such application is declined by the Investigator and the Institution, then the Hunter's Hope Foundation will have the right to file a patent application. On any patent filed by the Investigator or the Institution, the Hunter's Hope Foundation shall have a nonexclusive, nontransferable, irrevocable, paid-up license to practice, or have practiced for and on its behalf, any such invention and to grant sublicenses there under. The patent applications and patents obtained thereon shall embrace the United States and all countries outside of the United States. The inventions hereinabove contemplated shall include those made by employees or agents of the Institution or Investigator, and third parties under the control of the Institution or Investigator.
• Grantees are required to acknowledge Hunter's Hope grant support on any publication written or published as a result of such support. Such acknowledgement shall be to the effect:
  "This publication was made possible by grant support from the Hunter's Hope Foundation" OR
  "The project described was supported by a grant from the Hunter's Hope Foundation."